Liver-derived IGF-I regulates mean life span in mice.

Liver-derived IGF-I regulates mean life span in mice.

BACKGROUND: Transgenic mice with low levels of global insulin-like growth factor-I (IGF-I) throughout their life span, including pre- and postnatal development, have increased longevity. This study investigated whether specific deficiency of liver-derived, endocrine IGF-I is of importance for life s...

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Bibliographic Details
Main Authors: Johan Svensson, Klara Sjögren, Jenny Fäldt, Niklas Andersson, Olle Isaksson, John-Olov Jansson, Claes Ohlsson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3143189?pdf=render

Internet

http://europepmc.org/articles/PMC3143189?pdf=render

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