Enhanced gut barrier integrity sensitizes colon cancer to immune therapy

Enhanced gut barrier integrity sensitizes colon cancer to immune therapy

Oral IL-10 suppressed tumor growth in the APCmin/+ mouse/Bacteroides fragilis colon cancer model while a similar formulation of IL-12 exacerbated disease. In contrast, combined treatment with IL-10 and IL-12 resulted in near-complete tumor eradication and a significant extension of survival. The cyt...

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Bibliographic Details
Main Authors: Neal Bhutiani, Qingsheng Li, Charles D. Anderson, Heather C. Gallagher, Magdia De Jesus, Rajbir Singh, Venkatkrishna R. Jala, Mostafa Fraig, Tao Gu, Nejat K. Egilmez
Format: Article
Language:English
Published: Taylor & Francis Group 2018-11-01
Series:OncoImmunology
Subjects:
il-10
il-12
il-17
colon cancer
gut epithelial barrier
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1498438

Internet

http://dx.doi.org/10.1080/2162402X.2018.1498438

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