Validation of a commercial antibody to detect endogenous human nicastrin by immunoblot [version 2; peer review: 2 approved, 1 approved with reservations]
Nicastrin (NCSTN) is a transmembrane glycoprotein that is part of the gamma-secretase complex. Gamma-secretase is a protease complex that cleaves type-I single-pass transmembrane proteins. There are many potential substrates for this complex, including NOTCH receptors and amyloid precursor proteins...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
F1000 Research Ltd
2020-01-01
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| Series: | F1000Research |
| Online Access: | https://f1000research.com/articles/8-1211/v2 |