Diurnal patterns of soluble amyloid precursor protein metabolites in the human central nervous system.

Diurnal patterns of soluble amyloid precursor protein metabolites in the human central nervous system.

The amyloid-β (Aβ) protein is diurnally regulated in both the cerebrospinal fluid and blood in healthy adults; circadian amplitudes decrease with aging and the presence of cerebral Aβ deposits. The cause of the Aβ diurnal pattern is poorly understood. One hypothesis is that the Amyloid Precursor Pro...

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Bibliographic Details
Main Authors: Justyna A Dobrowolska, Tom Kasten, Yafei Huang, Tammie L S Benzinger, Wendy Sigurdson, Vitaliy Ovod, John C Morris, Randall J Bateman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3960093?pdf=render

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http://europepmc.org/articles/PMC3960093?pdf=render

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