Deciphering of the Human Interferon-Regulated Proteome by Mass Spectrometry-Based Quantitative Analysis Reveals Extent and Dynamics of Protein Induction and Repression

Deciphering of the Human Interferon-Regulated Proteome by Mass Spectrometry-Based Quantitative Analysis Reveals Extent and Dynamics of Protein Induction and Repression

Interferons (IFNs) are pleotropic cytokines secreted upon encounter of pathogens and tumors. Applying their antipathogenic, antiproliferative, and immune stimulatory capacities, recombinant IFNs are frequently prescribed as drugs to treat different diseases. IFNs act by changing the gene expression...

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Bibliographic Details
Main Authors: Dominik A. Megger, Jos Philipp, Vu Thuy Khanh Le-Trilling, Barbara Sitek, Mirko Trilling
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Immunology
Subjects:
interferon
IFN-stimulated gene
IFNalpha
IFNgamma
mass spectrometry
proteome
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01139/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01139/full

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