An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo

An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo

Mutations associated with SCN5A, which encodes the major cardiac sodium channel, influence impulse conduction and are associated with arrhythmia disorders. Here, the authors identify an evolutionary conserved, super enhancer-like, regulatory cluster downstream of SCN5A and show that it controls the...

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Bibliographic Details
Main Authors: Joyce C. K. Man, Rajiv A. Mohan, Malou van den Boogaard, Catharina R. E. Hilvering, Catherine Jenkins, Vincent Wakker, Valerio Bianchi, Wouter de Laat, Phil Barnett, Bastiaan J. Boukens, Vincent M. Christoffels
Format: Article
Language:English
Published: Nature Publishing Group 2019-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12856-5

Internet

https://doi.org/10.1038/s41467-019-12856-5

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