Astrocytic Sonic Hedgehog Alleviates Intracerebral Hemorrhagic Brain Injury via Modulation of Blood-Brain Barrier Integrity

Astrocytic Sonic Hedgehog Alleviates Intracerebral Hemorrhagic Brain Injury via Modulation of Blood-Brain Barrier Integrity

Background: Intracerebral hemorrhage (ICH) is a fatal subtype of stroke that lacks effective therapy. Blood-brain barrier (BBB) damage is a hallmark of ICH-induced brain injury that leads to edema formation, leukocytes infiltration, influx of blood components into the perihematomal (PHE) region, and...

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Bibliographic Details
Main Authors: Gebeili Xing, Tianman Zhao, Xiyue Zhang, He Li, Xiuping Li, Pan Cui, Minshu Li, Daojing Li, Nan Zhang, Wei Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
cyclopamine
tight junctions
sonic hedgehog signaling pathway
blood brain barrier
cerebral hemorrhage
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2020.575690/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2020.575690/full

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