A MicroRNA-Based Network Provides Potential Predictive Signatures and Reveals the Crucial Role of PI3K/AKT Signaling for Hepatic Lineage Maturation

A MicroRNA-Based Network Provides Potential Predictive Signatures and Reveals the Crucial Role of PI3K/AKT Signaling for Hepatic Lineage Maturation

BackgroundFunctions of miRNAs involved in tumorigenesis are well reported, yet, their roles in normal cell lineage commitment remain ambiguous. Here, we investigated a specific “transcription factor (TF)-miRNA-Target” regulatory network during the lineage maturation of biliary tree stem cells (BTSCs...

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Bibliographic Details
Main Authors: Xicheng Wang, Wencheng Zhang, Yong Yang, Jiansong Wang, Hua Qiu, Lijun Liao, Tsunekazu Oikawa, Eliane Wauthier, Praveen Sethupathy, Lola M. Reid, Zhongmin Liu, Zhiying He
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
microRNAs
PI3K/AKT signaling
biliary tree stem cells
hepatic lineage
let-7 family
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.670059/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.670059/full

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