Gap junction reduction in cardiomyocytes following transforming growth factor-β treatment and Trypanosoma cruzi infection

Gap junction reduction in cardiomyocytes following transforming growth factor-β treatment and Trypanosoma cruzi infection

Gap junction connexin-43 (Cx43) molecules are responsible for electrical impulse conduction in the heart and are affected by transforming growth factor-β (TGF-β). This cytokine increases during Trypanosoma cruzi infection, modulating fibrosis and the parasite cell cycle. We studied...

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Bibliographic Details
Main Authors: Mariana C Waghabi, Robson Coutinho-Silva, Jean-Jacques Feige, Maria de Lourdes Higuchi, David Becker, Geoffrey Burnstock, Tânia C de Araújo-Jorge
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2009-12-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
gap junction
heart
Chagas disease
transforming growth factor- β
connexin 43
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000800004

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000800004

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