Low Avidity T Cells Do Not Hinder High Avidity T Cell Responses Against Melanoma

The efficacy of T cells depends on their functional avidity, i. e., the strength of T cell interaction with cells presenting cognate antigen. The overall T cell response is composed of multiple T cell clonotypes, involving different T cell receptors and variable levels of functional avidity. Recentl...

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Bibliographic Details
Main Authors: Kalliopi Ioannidou, Olivier Randin, Aikaterini Semilietof, Hélène Maby-El Hajjami, Petra Baumgaertner, Dominique Vanhecke, Daniel E. Speiser
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02115/full