In silico design and molecular docking study of CDK2 inhibitors with potent cytotoxic activity against HCT116 colorectal cancer cell line

In silico design and molecular docking study of CDK2 inhibitors with potent cytotoxic activity against HCT116 colorectal cancer cell line

Abstract Background Colorectal cancer is common to both sexes; third in terms of morbidity and second in terms of mortality, accounting for 10% and 9.2% of cancer cases in men and women globally. Although drugs such as bevacizumab, Camptosar, and cetuximab are being used to manage colorectal cancer,...

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Bibliographic Details
Main Authors: Fabian Adakole Ikwu, Yusuf Isyaku, Babatunde Samuel Obadawo, Hadiza Abdulrahman Lawal, Samuel Akolade Ajibowu
Format: Article
Language:English
Published: SpringerOpen 2020-09-01
Series:Journal of Genetic Engineering and Biotechnology
Subjects:
Colorectal cancer
Cyclin dependent kinase 2 enzyme
Computer-aided drug design
Quantitative structure activity relationship
Molecular docking
Imidazole
Online Access:http://link.springer.com/article/10.1186/s43141-020-00066-2

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http://link.springer.com/article/10.1186/s43141-020-00066-2

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