An S188V mutation alters substrate specificity of non-stereospecific α-haloalkanoic acid dehalogenase E (DehE).

An S188V mutation alters substrate specificity of non-stereospecific α-haloalkanoic acid dehalogenase E (DehE).

The non-stereospecific α-haloalkanoic acid dehalogenase E (DehE) degrades many halogenated compounds but is ineffective against β-halogenated compounds such as 3-chloropropionic acid (3CP). Using molecular dynamics (MD) simulations and site-directed mutagenesis we show here that introducing the muta...

Full description

Bibliographic Details
Main Authors: Azzmer Azzar Abdul Hamid, Tengku Haziyamin Tengku Abdul Hamid, Roswanira Abdul Wahab, Mohd Shahir Shamsir Omar, Fahrul Huyop
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4376737?pdf=render

Internet

http://europepmc.org/articles/PMC4376737?pdf=render

Similar Items