Single molecule analysis reveals monomeric XPA bends DNA and undergoes episodic linear diffusion during damage search

Single molecule analysis reveals monomeric XPA bends DNA and undergoes episodic linear diffusion during damage search

It is not fully understood how XPA interacts with a DNA lesion during nucleotide excision repair. Here, the authors use single molecule analysis to study XPA–DNA interactions, including the DNA bend angle, protein stoichiometry, and diffusive properties during damage search.

Bibliographic Details
Main Authors: Emily C. Beckwitt, Sunbok Jang, Isadora Carnaval Detweiler, Jochen Kuper, Florian Sauer, Nina Simon, Johanna Bretzler, Simon C. Watkins, Thomas Carell, Caroline Kisker, Bennett Van Houten
Format: Article
Language:English
Published: Nature Publishing Group 2020-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15168-1

Internet

https://doi.org/10.1038/s41467-020-15168-1

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