Putative Activation of the CB1 Cannabinoid Receptors Prevents Anxiety-Like Behavior, Oxidative Stress, and GABA Decrease in the Brain of Zebrafish Submitted to Acute Restraint Stress

Putative Activation of the CB1 Cannabinoid Receptors Prevents Anxiety-Like Behavior, Oxidative Stress, and GABA Decrease in the Brain of Zebrafish Submitted to Acute Restraint Stress

Anxiety disorder is a well-recognized condition observed in subjects submitted to acute stress. Although the brain mechanisms underlying this disorder remain unclear, the available evidence indicates that oxidative stress and GABAergic dysfunction mediate the generation of stress-induced anxiety. Ca...

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Bibliographic Details
Main Authors: Waldo Lucas Luz, Mateus Santos-Silva, Patrick Bruno Cardoso, Nadyme Assad, Edinaldo Rogério da Silva Moraes, Alan Barroso Araújo Grisólia, Danielle Valente Braga, Luana Ketlen Reis Leão, Suellen Alessandra Soares de Moraes, Adelaide da Conceição Passos, Evander de Jesus Oliveira Batista, Amauri Gouveia, Karen R. H. Matos Oliveira, Anderson Manoel Herculano
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
anxiety
acute stress
CB1 receptors
oxidative stress
GABA
zebrafish
Online Access:https://www.frontiersin.org/articles/10.3389/fnbeh.2020.598812/full

Internet

https://www.frontiersin.org/articles/10.3389/fnbeh.2020.598812/full

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