Bag-1 stimulates Bad phosphorylation through activation of Akt and Raf kinases to mediate cell survival in breast cancer

Bag-1 stimulates Bad phosphorylation through activation of Akt and Raf kinases to mediate cell survival in breast cancer

Abstract Background Bag-1 (Bcl-2-associated athanogene) is a multifunctional anti-apoptotic protein frequently overexpressed in cancer. Bag-1 interacts with a variety of cellular targets including Hsp70/Hsc70 chaperones, Bcl-2, nuclear hormone receptors, Akt and Raf kinases. In this study, we invest...

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Bibliographic Details
Main Authors: Tugba Kizilboga, Emine Arzu Baskale, Jale Yildiz, Izzet Mehmet Akcay, Ebru Zemheri, Nisan Denizce Can, Can Ozden, Salih Demir, Fikret Ezberci, Gizem Dinler-Doganay
Format: Article
Language:English
Published: BMC 2019-12-01
Series:BMC Cancer
Subjects:
Bag-1
Bad phosphorylation
Akt
Raf kinase
Breast cancer
Apoptosis
Online Access:https://doi.org/10.1186/s12885-019-6477-4

Internet

https://doi.org/10.1186/s12885-019-6477-4

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