Conditional Inactivation of Nf1 and Pten in Schwann Cells Results in Abnormal Neuromuscular Junction Maturation

Conditional Inactivation of Nf1 and Pten in Schwann Cells Results in Abnormal Neuromuscular Junction Maturation

The neuromuscular junction (NMJ) consists of three components, namely presynaptic motor neurons, postsynaptic muscle fibers and perisynaptic Schwann cells (PSCs). The role of Schwann cells (SCs) in regulating NMJ structural and functional development remains unclear. In this study, mice with conditi...

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Bibliographic Details
Main Authors: Xiao-Xiao Li, Shi-Jie Zhang, Amy P. Chiu, Lilian H. Lo, Jeffery C. To, He-Ning Cui, Dewi K. Rowlands, Vincent W. Keng
Format: Article
Language:English
Published: Oxford University Press 2019-01-01
Series:G3: Genes, Genomes, Genetics
Subjects:
neuromuscular junction
Schwann cell
Neurofibromin 1
phosphatase and tensin homolog
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.118.200795

Internet

http://g3journal.org/lookup/doi/10.1534/g3.118.200795

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