The prostate specific membrane antigen regulates the expression of IL-6 and CCL5 in prostate tumour cells by activating the MAPK pathways.

The prostate specific membrane antigen regulates the expression of IL-6 and CCL5 in prostate tumour cells by activating the MAPK pathways.

The interleukin-6 (IL-6) and the chemokine CCL5 are implicated in the development and progression of several forms of tumours including that of the prostate. The expression of the prostate specific membrane antigen (PSMA) is augmented in high-grade and metastatic tumors. Observations of the clinical...

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Main Authors: Marco Colombatti, Silvia Grasso, Alessandra Porzia, Giulio Fracasso, Maria Teresa Scupoli, Sara Cingarlini, Ornella Poffe, Hassan Y Naim, Martin Heine, Giuseppe Tridente, Fabrizio Mainiero, Dunia Ramarli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2643478?pdf=render

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http://europepmc.org/articles/PMC2643478?pdf=render

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