The Role of KDM2B and EZH2 in Regulating the Stemness in Colorectal Cancer Through the PI3K/AKT Pathway

The Role of KDM2B and EZH2 in Regulating the Stemness in Colorectal Cancer Through the PI3K/AKT Pathway

Background: The incidence of colorectal cancer (CRC) has been increasing worldwide in recent years. Targeting cancer stem cells (CSCs) in CRC remains a difficult challenge. KDM2B and EZH2 play important role in the maintenance of CSCs' self-renewal capacity and tumorigenic ability; however, the...

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Bibliographic Details
Main Authors: Jaceline Gisliane Pires Sanches, Bo Song, Qingqing Zhang, Xinye Cui, Iddrisu Baba Yabasin, Michael Ntim, Xinlong Li, Jiabei He, Yao Zhang, Jun Mao, Ying Lu, Lianhong Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Oncology
Subjects:
KDM2B
EZH2
stemness
colorectal cancer
PI3K/AKT
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.637298/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.637298/full

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