Synthesis of Functionalised Nucleosides for Incorporation into Nucleic Acid-Based Serine Protease Mimics

The synthesis of nucleosides modified with an extra imidazole, carboxyl and hydroxyl group is described. These nucleosides can be incorporated into an oligonucleotide duplex, thus generating a novel type of serine protease mimic.

Bibliographic Details
Main Authors: Annemieke Madder, Mieke A. Catry
Format: Article
Language:English
Published: MDPI AG 2007-01-01
Series:Molecules
Subjects:
Online Access:http://www.mdpi.com/1420-3049/12/1/114/