Escin Increases the Survival Rate of LPS-Induced Septic Mice Through Inhibition of HMGB1 Release from Macrophages

Escin Increases the Survival Rate of LPS-Induced Septic Mice Through Inhibition of HMGB1 Release from Macrophages

Background: Previous studies have described the effects of Escin on improving the survival rate of endotoxemic animals. The purpose of this study was to explore the molecular mechanisms of this potentially beneficial treatment. Methods: First, the survival rate of endotoxemic mice was monitored for...

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Bibliographic Details
Main Authors: Yajun Cheng, Hongrui Wang, Min Mao, Chao Liang, Yu Zhang, Deijun Yang, Ziran Wei, Shunxiang Gao, Bo Hu, Lianghua Wang, Qingping Cai
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
Escin
High motility group box 1(HMGB1)
Sepsis
NF-κB
Online Access:http://www.karger.com/Article/FullText/430320

Internet

http://www.karger.com/Article/FullText/430320

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