Elevated Hapln2 expression contributes to protein aggregation and neurodegeneration in an animal model of Parkinson's disease

Elevated Hapln2 expression contributes to protein aggregation and neurodegeneration in an animal model of Parkinson's disease

Parkinson’s disease (PD), the second most common age-associated progressive neurodegenerative disorder, is characterized by the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SN). The pathogenesis of PD and the mechanisms underlying the degeneration of DA neurons are still...

Full description

Bibliographic Details
Main Authors: Qinqin Wang, Qinbo Zhou, Shuzhen Zhang, Wei Shao, Yanqing Yin, Yandong Li, Jincan Hou, Xinhua Zhang, Yongshun Guo, Xiaomin Wang, Xiaosong Gu, Jiawei Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
Dopaminergic Neurons
Parkinson’s disease
ubiquitin-proteasome system
Aggregation.
hyaluronan and proteoglycan binding link protein 2
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00197/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00197/full

Similar Items