Gamma-tocotrienol modulation of senescence-associated gene expression prevents cellular aging in human diploid fibroblasts

Gamma-tocotrienol modulation of senescence-associated gene expression prevents cellular aging in human diploid fibroblasts

OBJECTIVE: Human diploid fibroblasts undergo a limited number of cellular divisions in culture and progressively reach a state of irreversible growth arrest, a process termed cellular aging. The beneficial effects of vitamin E in aging have been established, but studies to determine the mechanisms o...

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Bibliographic Details
Main Authors: Suzana Makpol, Azalina Zainuddin, Kien Hui Chua, Yasmin Anum Mohd Yusof, Wan Zurinah Wan Ngah
Format: Article
Language:English
Published: Faculdade de Medicina / USP 2012-01-01
Series:Clinics
Subjects:
Vitamin E
Molecular mechanism
Cellular aging
Senescence-associated genes
Human diploid fibroblasts
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322012000200008

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322012000200008

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