In vitro co-culture systems for studying molecular basis of cellular interaction between Aire-expressing medullary thymic epithelial cells and fresh thymocytes

In vitro co-culture systems for studying molecular basis of cellular interaction between Aire-expressing medullary thymic epithelial cells and fresh thymocytes

We previously established three mouse cell lines (Aire+TEC1, Aire+TEC2 and Aire+DC) from the medullary thymic epithelial cells (mTECs) and dendritic cells (mDCs). These cells constitutively expressed “autoimmune regulator (Aire) gene” and they exhibited various features of self antigen-presenting ce...

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Bibliographic Details
Main Authors: Yoshitaka Yamaguchi, Jun Kudoh, Tetsuhiko Yoshida, Nobuyoshi Shimizu
Format: Article
Language:English
Published: The Company of Biologists 2014-10-01
Series:Biology Open
Subjects:
autoimmunity
AIRE
Aire+ cell lines
central self-tolerance
thymic crosstalk
Online Access:http://bio.biologists.org/content/3/11/1071

Internet

http://bio.biologists.org/content/3/11/1071

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