Head and neck squamous cell carcinoma cell lines have an immunomodulatory effect on macrophages independent of hypoxia and toll-like receptor 9

Head and neck squamous cell carcinoma cell lines have an immunomodulatory effect on macrophages independent of hypoxia and toll-like receptor 9

Abstract Background A low tissue oxygen level, < 1% O2, is a typical characteristic inside of solid tumors in head and neck cancer (HNSCC) affecting a wide array of cell populations, such as macrophages. However, the mechanisms of how hypoxia influences macrophages are not yet fully elucidated. O...

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Bibliographic Details
Main Authors: Tamiko Ishizu, Dominik Eichin, Artur Padzik, Sanni Tuominen, Reidar Grénman, Marko Salmi, Tove J. Grönroos, Johanna M. Tuomela
Format: Article
Language:English
Published: BMC 2021-09-01
Series:BMC Cancer
Subjects:
Immune evasion
Anti-cancer immunomodulation
Innate immune response
TLR9
Macrophage polarization
Hypoxia
Online Access:https://doi.org/10.1186/s12885-021-08357-8

Internet

https://doi.org/10.1186/s12885-021-08357-8

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