Estrogen Receptor-Alpha (ESR1) Governs the Lower Female Reproductive Tract Vulnerability to Candida albicans

Estrogen Receptor-Alpha (ESR1) Governs the Lower Female Reproductive Tract Vulnerability to Candida albicans

Estradiol-based therapies predispose women to vaginal infections. Moreover, it has long been known that neutrophils are absent from the vaginal lumen during the ovulatory phase (high estradiol). However, the mechanisms that regulate neutrophil influx to the vagina remain unknown. We investigated the...

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Bibliographic Details
Main Authors: Laura Salinas-Muñoz, Raúl Campos-Fernández, Enrique Mercader, Irene Olivera-Valle, Carlota Fernández-Pacheco, Lara Matilla, Julio García-Bordas, Jennifer C. Brazil, Charles A. Parkos, Fernando Asensio, Maria A. Muñoz-Fernández, Andrés Hidalgo, Paloma Sánchez-Mateos, Rafael Samaniego, Miguel Relloso
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
estradiol
ESR1
progesterone
neutrophils
transepithelial migration
cervix
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01033/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01033/full

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