Functional assessment of population and tumor-associated APE1 protein variants.

Functional assessment of population and tumor-associated APE1 protein variants.

Apurinic/apyrimidinic endonuclease 1 (APE1) is the predominant AP site repair enzyme in mammals. APE1 also maintains 3'-5' exonuclease and 3'-repair activities, and regulates transcription factor DNA binding through its REF-1 function. Since complete or severe APE1 deficiency leads to...

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Bibliographic Details
Main Authors: Jennifer L Illuzzi, Nicole A Harris, Brittney A Manvilla, Daemyung Kim, Mengxia Li, Alexander C Drohat, David M Wilson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3679070?pdf=render

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http://europepmc.org/articles/PMC3679070?pdf=render

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