Decoding the evolutionary response to prostate cancer therapy by plasma genome sequencing

Decoding the evolutionary response to prostate cancer therapy by plasma genome sequencing

Abstract Background Investigating genome evolution in response to therapy is difficult in human tissue samples. To address this challenge, we develop an unbiased whole-genome plasma DNA sequencing approach that concurrently measures genomic copy number and exome mutations from archival cryostored pl...

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Bibliographic Details
Main Authors: Naveen Ramesh, Emi Sei, Pei Ching Tsai, Shanshan Bai, Yuehui Zhao, Patricia Troncoso, Paul G. Corn, Christopher Logothetis, Amado J. Zurita, Nicholas E. Navin
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Genome Biology
Subjects:
Tumor evolution
Liquid biopsies
Non-invasive
Online Access:http://link.springer.com/article/10.1186/s13059-020-02045-9

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http://link.springer.com/article/10.1186/s13059-020-02045-9

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