p38α MAPK and Type I Inhibitors: Binding Site Analysis and Use of Target Ensembles in Virtual Screening

p38α MAPK and Type I Inhibitors: Binding Site Analysis and Use of Target Ensembles in Virtual Screening

Mitogen-activated protein kinase p38α plays an essential role in the regulation of pro-inflammatory signaling, and selective blockade of this kinase could be efficacious in many pathological processes. Despite considerable research efforts focused on the discovery and development of p38α MAPK inhib...

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Bibliographic Details
Main Authors: Andrea Astolfi, Nunzio Iraci, Stefano Sabatini, Maria Letizia Barreca, Violetta Cecchetti
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:Molecules
Subjects:
p38α MAPK
docking
virtual screening
type I inhibitors
Online Access:http://www.mdpi.com/1420-3049/20/9/15842

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http://www.mdpi.com/1420-3049/20/9/15842

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