Pediatric and Adult High-Grade Glioma Stem Cell Culture Models Are Permissive to Lytic Infection with Parvovirus H-1

Pediatric and Adult High-Grade Glioma Stem Cell Culture Models Are Permissive to Lytic Infection with Parvovirus H-1

Combining virus-induced cytotoxic and immunotherapeutic effects, oncolytic virotherapy represents a promising therapeutic approach for high-grade glioma (HGG). A clinical trial has recently provided evidence for the clinical safety of the oncolytic parvovirus H-1 (H-1PV) in adult glioblastoma relaps...

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Bibliographic Details
Main Authors: Rafael Josupeit, Sebastian Bender, Sonja Kern, Barbara Leuchs, Thomas Hielscher, Christel Herold-Mende, Jörg R. Schlehofer, Christiane Dinsart, Olaf Witt, Jean Rommelaere, Jeannine Lacroix
Format: Article
Language:English
Published: MDPI AG 2016-05-01
Series:Viruses
Subjects:
oncolytic virus
parvovirus H-1
H-1PV
DIPG
pediatric glioblastoma
tumor initiating cells
glioma stem-like cells
high-grade glioma
Online Access:http://www.mdpi.com/1999-4915/8/5/138

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http://www.mdpi.com/1999-4915/8/5/138

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