Design of Druglike Small Molecules for Possible Inhibition of Antiapoptotic BCL-2, BCL-W, and BFL-1 Proteins
New druglike small molecules with possible anticancer applications were computationally designed. The molecules formed stable complexes with antiapoptotic BCL-2, BCL-W, and BFL-1 proteins. These findings are novel because, to the best of the author's knowledge, molecules that bind all three of...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2010-01-01
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| Series: | Biomedical Engineering and Computational Biology |
| Online Access: | https://doi.org/10.4137/BECB.S5575 |