A ROS-responsive polymeric prodrug nanosystem with self-amplified drug release for PSMA (−) prostate cancer specific therapy

A ROS-responsive polymeric prodrug nanosystem with self-amplified drug release for PSMA (−) prostate cancer specific therapy

Abstract Background The selectively accumulate in tumor site and completely release drug within cancer cells great limit the therapeutic effect of nano-drug delivery system. Moreover, absence of appropriate biomarker is one of the major challenges for prostate specific membrane antigen negative (PSM...

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Bibliographic Details
Main Authors: Yifan Wang, Yanqiu Zhang, Zhengxing Ru, Wei Song, Lin Chen, Hao Ma, Lizhu Sun
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Journal of Nanobiotechnology
Subjects:
ROS-responsive
Self-accelerating
PMSA
Intracellular ROS amplification
Online Access:http://link.springer.com/article/10.1186/s12951-019-0521-z

Internet

http://link.springer.com/article/10.1186/s12951-019-0521-z

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