1-Methyl-2-undecyl-4(1H)-quinolone, a derivative of quinolone alkaloid evocarpine, attenuates high phosphate-induced calcification of human aortic valve interstitial cells by inhibiting phosphate cotransporter PiT-1

1-Methyl-2-undecyl-4(1H)-quinolone, a derivative of quinolone alkaloid evocarpine, attenuates high phosphate-induced calcification of human aortic valve interstitial cells by inhibiting phosphate cotransporter PiT-1

An abnormally high serum phosphate level induces calcific aortic stenosis (CAS), which is characterized by ectopic valve calcification and stenosis of the orifice area. Inhibition of ectopic calcification is a critical function of any internal medical therapy for CAS disease. The aim of the present...

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Bibliographic Details
Main Authors: Kazuhiko Seya, Ken-Ichi Furukawa, Mari Chiyoya, Zaiqiang Yu, Haruhisa Kikuchi, Kazuyuki Daitoku, Shigeru Motomura, Manabu Murakami, Yoshiteru Oshima, Ikuo Fukuda
Format: Article
Language:English
Published: Elsevier 2016-05-01
Series:Journal of Pharmacological Sciences
Subjects:
Aortic valve interstitial cells
Calcification
1-Methyl-2-undecyl-4(1H)-quinolone
High phosphate
PiT-1
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861316300305

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http://www.sciencedirect.com/science/article/pii/S1347861316300305

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