CREB activity in dopamine D1 receptor expressing neurons regulates cocaine-induced behavioral effects

CREB activity in dopamine D1 receptor expressing neurons regulates cocaine-induced behavioral effects

IIt is suggested that striatal cAMP responsive element binding protein (CREB) regulates sensitivity to psychostimulants. To test the cell-specificity of this hypothesis we examined the effects of a dominant-negative CREB protein variant expressed in dopamine receptor D1 (D1R) neurons on cocaine-indu...

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Bibliographic Details
Main Authors: Ainhoa eBilbao, Claus eRieker, Nazzareno eCannella, Rosanna eParlato, Slawomir eGolda, Marcin ePiechota, Michal eKorostynski, David eEngblom, Ryszard ePrzewlocki, Günther eSchütz, Rainer eSpanagel, Jan eRodriguez Parkitna
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
CREB
addiction.
activity-dependent gene expression
dominant negative CREB
dopamine receptor D1
cocaine-related behavior
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00212/full

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http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00212/full

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