Reduced Excitability and Increased Neurite Complexity of Cortical Interneurons in a Familial Mouse Model of Amyotrophic Lateral Sclerosis

Reduced Excitability and Increased Neurite Complexity of Cortical Interneurons in a Familial Mouse Model of Amyotrophic Lateral Sclerosis

Cortical interneurons play a crucial role in regulating inhibitory-excitatory balance in brain circuits, filtering synaptic information and dictating the activity of pyramidal cells through the release of GABA. In the fatal motor neuron (MN) disease, amyotrophic lateral sclerosis (ALS), an imbalance...

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Bibliographic Details
Main Authors: Rosemary M. Clark, Mariana Brizuela, Catherine A. Blizzard, Tracey C. Dickson
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
excitability
structure
interneuron
cortex
SOD1 G93A mutant
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00328/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2018.00328/full

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