Early changes in the hypothalamic region in prodromal Huntington disease revealed by MRI analysis

Early changes in the hypothalamic region in prodromal Huntington disease revealed by MRI analysis

Huntington disease (HD) is a fatal neurodegenerative disorder caused by an expanded CAG repeat. Its length can be used to estimate the time of clinical diagnosis, which is defined by overt motor symptoms. Non-motor symptoms begin before motor onset, and involve changes in hypothalamus-regulated func...

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Bibliographic Details
Main Authors: Charlotte Soneson, Magnus Fontes, Yongxia Zhou, Vladimir Denisov, Jane S. Paulsen, Deniz Kirik, Åsa Petersén
Format: Article
Language:English
Published: Elsevier 2010-12-01
Series:Neurobiology of Disease
Subjects:
Huntingtin
Hypothalamus
Imaging
Basal ganglia
Neuroendocrine
Atrophy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110002378

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