Early changes in the hypothalamic region in prodromal Huntington disease revealed by MRI analysis

Huntington disease (HD) is a fatal neurodegenerative disorder caused by an expanded CAG repeat. Its length can be used to estimate the time of clinical diagnosis, which is defined by overt motor symptoms. Non-motor symptoms begin before motor onset, and involve changes in hypothalamus-regulated func...

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Bibliographic Details
Main Authors: Charlotte Soneson, Magnus Fontes, Yongxia Zhou, Vladimir Denisov, Jane S. Paulsen, Deniz Kirik, Åsa Petersén
Format: Article
Language:English
Published: Elsevier 2010-12-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110002378