Selective Antagonism of A1 Adenosinergic Receptors Strengthens the Neuromodulation of the Sensorimotor Network During Epidural Spinal Stimulation

Selective Antagonism of A1 Adenosinergic Receptors Strengthens the Neuromodulation of the Sensorimotor Network During Epidural Spinal Stimulation

Although epidural spinal stimulation (ESS) results in promising therapeutic effects in individuals with spinal cord injury (SCI), its potential to generate functional motor recovery varies between individuals and remains largely unclear. However, both preclinical and clinical studies indicate the ca...

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Bibliographic Details
Main Authors: Giuliano Taccola, Betsy Habeth Salazar, Rosamaria Apicella, Matthew Kevin Hogan, Philip John Horner, Dimitry Sayenko
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Systems Neuroscience
Subjects:
motor control
spinal electrical stimulation
spinal reflexes
adenosine receptors
spinal transection
trains of pulses
Online Access:https://www.frontiersin.org/article/10.3389/fnsys.2020.00044/full

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https://www.frontiersin.org/article/10.3389/fnsys.2020.00044/full

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