Fucoidan from <i>Laminaria japonica</i> Inhibits Expression of GLUT9 and URAT1 via PI3K/Akt, JNK and NF-κB Pathways in Uric Acid-Exposed HK-2 Cells

Fucoidan from <i>Laminaria japonica</i> Inhibits Expression of GLUT9 and URAT1 via PI3K/Akt, JNK and NF-κB Pathways in Uric Acid-Exposed HK-2 Cells

This work aimed to investigate the effect of fucoidan (FPS) on urate transporters induced by uric acid (UA). The results showed that UA stimulated the expression of glucose transporter 9 (GLUT9) and urate transporter 1 (URAT1) in HK-2 cells, and FPS could reverse the effect. Moreover, UA could activ...

Full description

Bibliographic Details
Main Authors: Yu Zhang, Xiaohui Tan, Zhen Lin, Fangping Li, Chunyan Yang, Haiying Zheng, Lingyu Li, Huazhong Liu, Jianghua Shang
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Marine Drugs
Subjects:
fucoidan
uric acid
urate transporter 1
glucose transporter 9
Online Access:https://www.mdpi.com/1660-3397/19/5/238

Internet

https://www.mdpi.com/1660-3397/19/5/238

Similar Items