Stereoselective Enzymatic Reduction of 1,4-Diaryl-1,4-Diones to the Corresponding Diols Employing Alcohol Dehydrogenases

Stereoselective Enzymatic Reduction of 1,4-Diaryl-1,4-Diones to the Corresponding Diols Employing Alcohol Dehydrogenases

Due to the steric hindrance of the starting prochiral ketones, the preparation of chiral 1,4-diaryl-1,4-diols through the asymmetric hydrogen transfer reaction has been mainly restricted to the use of metal-based catalysts, oxazaborolidines, or organocatalysts. Herein, we demonstrated the versatilit...

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Bibliographic Details
Main Authors: Ángela Mourelle-Insua, Gonzalo de Gonzalo, Iván Lavandera, Vicente Gotor-Fernández
Format: Article
Language:English
Published: MDPI AG 2018-04-01
Series:Catalysts
Subjects:
alcohol dehydrogenases
asymmetric synthesis
bioreduction
1,4-diols
diketones
Online Access:http://www.mdpi.com/2073-4344/8/4/150

Internet

http://www.mdpi.com/2073-4344/8/4/150

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