A novel role for NUAK1 in promoting ovarian cancer metastasis through regulation of fibronectin production in spheroids

A novel role for NUAK1 in promoting ovarian cancer metastasis through regulation of fibronectin production in spheroids

Epithelial ovarian cancer (EOC) has a unique mode of metastasis, where cells shed from the primary tumour, form aggregates called spheroids to evade anoikis, spread through the peritoneal cavity, and adhere to secondary sites. We previously showed that the master kinase Liver kinase B1 (LKB1) is req...

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Bibliographic Details
Main Authors: Jamie Lee Fritz, Olga Collins, Parima Saxena, Adrian Buensuceso, Yudith Ramos Valdes, Kyle E. Francis, Kevin R. Brown, Brett Larsen, Karen Colwill, Anne-Claude Gingras, Robert Rottapel, Trevor G. Shepherd
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cancers
Subjects:
ovarian cancer
spheroid
LKB1
NUAK1
metastasis
fibronectin
Online Access:https://www.mdpi.com/2072-6694/12/5/1250

Internet

https://www.mdpi.com/2072-6694/12/5/1250

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