Acquired Senescent T-Cell Phenotype Correlates with Clinical Severity in GATA Binding Protein 2-Deficient Patients

Acquired Senescent T-Cell Phenotype Correlates with Clinical Severity in GATA Binding Protein 2-Deficient Patients

GATA binding protein 2 (GATA2) deficiency is a rare disorder of hematopoiesis, lymphatics, and immunity caused by spontaneous or autosomal dominant mutations in the GATA2 gene. Clinical manifestations range from neutropenia, lymphedema, deafness, to severe viral and mycobacterial infections, bone ma...

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Bibliographic Details
Main Authors: Raquel Ruiz-García, Carmen Rodríguez-Vigil, Francisco Manuel Marco, Fernando Gallego-Bustos, María José Castro-Panete, Laura Diez-Alonso, Carlos Muñoz-Ruiz, Jesús Ruiz-Contreras, Estela Paz-Artal, Luis Ignacio González-Granado, Luis Miguel Allende
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Immunology
Subjects:
primary immunodeficiency
GATA binding protein 2
T-cell
natural killer-cell
myelodysplastic syndrome
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00802/full

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http://journal.frontiersin.org/article/10.3389/fimmu.2017.00802/full

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