A Light-Inducible Split-dCas9 System for Inhibiting the Progression of Bladder Cancer Cells by Activating p53 and E-cadherin

A Light-Inducible Split-dCas9 System for Inhibiting the Progression of Bladder Cancer Cells by Activating p53 and E-cadherin

Optogenetic systems have been increasingly investigated in the field of biomedicine. Previous studies had found the inhibitory effect of the light-inducible genetic circuits on cancer cell growth. In our study, we applied an AND logic gates to the light-inducible genetic circuits to inhibit the canc...

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Bibliographic Details
Main Authors: Xinbo Huang, Qun Zhou, Mingxia Wang, Congcong Cao, Qian Ma, Jing Ye, Yaoting Gui
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Molecular Biosciences
Subjects:
CRISPR
split-dCas9
light-inducible
bladder cancer
logic gate
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2020.627848/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2020.627848/full

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