The Cattle Fever Tick, Rhipicephalus microplus, as a Model for Forward Pharmacology to Elucidate Kinin GPCR Function in the Acari

The Cattle Fever Tick, Rhipicephalus microplus, as a Model for Forward Pharmacology to Elucidate Kinin GPCR Function in the Acari

The success of the acaricide amitraz, a ligand of the tick tyramine/octopamine receptor (a G protein-coupled receptor; GPCR), stimulated interest on arthropod-specific GPCRs as targets to control tick populations. This search advances tick physiology because little is known about the pharmacology of...

Full description

Bibliographic Details
Main Authors: Caixing Xiong, Dwight Baker, Patricia V. Pietrantonio
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Physiology
Subjects:
leucokinin receptor
endogenous tick kinins
neuropeptide GPCR
dual-addition assay
small molecule screen
neurokinin antagonists
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.01008/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.01008/full

Similar Items