In Vitro Effects of Ligand Bias on Primate Mu Opioid Receptor Downstream Signaling

In Vitro Effects of Ligand Bias on Primate Mu Opioid Receptor Downstream Signaling

Interest has emerged in biased agonists at the mu opioid receptor (MOR) as a possible means for maintaining potent analgesis with reduced side effect profiles. While approaches measuring in vitro biased agonism are used in the development of these compounds, their therapeutic utility will ultimately...

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Bibliographic Details
Main Authors: Xiao Zhang, Shaurita D. Hutchins, Bruce E. Blough, Eric J. Vallender
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
opioid
biased agonism
morphine
nonhuman primate
second messenger signaling
Online Access:https://www.mdpi.com/1422-0067/21/11/3999

Internet

https://www.mdpi.com/1422-0067/21/11/3999

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