Cardiomyocyte‐derived exosomal microRNA‐92a mediates post‐ischemic myofibroblast activation both in vitro and ex vivo

Abstract Aims We hypothesize that specific microRNAs (miRNAs) within cardiomyocyte‐derived exosomes play a pivotal role in the phenoconversion of cardiac myofibroblasts following myocardial infarction (MI). Methods and results We used an established murine model of MI, obtained in vivo via ligation...

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Bibliographic Details
Main Authors: Xujun Wang, Marco Bruno Morelli, Alessandro Matarese, Celestino Sardu, Gaetano Santulli
Format: Article
Language:English
Published: Wiley 2020-02-01
Series:ESC Heart Failure
Subjects:
Online Access:https://doi.org/10.1002/ehf2.12584