Extracellular ATP and Toll-like receptor 2 agonists trigger in human monocytes an activation program that favors T helper 17.

Extracellular ATP and Toll-like receptor 2 agonists trigger in human monocytes an activation program that favors T helper 17.

Strategically-paired Toll-like receptor (TLR) ligands induce a unique dendritic cell (DC) phenotype that polarizes Th1 responses. We therefore investigated pairing single TLR ligands with a non TLR-mediated danger signal to cooperatively induce distinct DC properties from cultured human monocytes. A...

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Bibliographic Details
Main Authors: Christopher Paustian, Patricia Taylor, Terrence Johnson, Min Xu, Nancy Ramirez, Kenneth S Rosenthal, Suyu Shu, Peter A Cohen, Brian J Czerniecki, Gary K Koski
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3561418?pdf=render

Internet

http://europepmc.org/articles/PMC3561418?pdf=render

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