Improved genetically-encoded, FlincG-type fluorescent biosensors for neural cGMP imaging

Improved genetically-encoded, FlincG-type fluorescent biosensors for neural cGMP imaging

Genetically-encoded biosensors are powerful tools for understanding cellular signal transduction mechanisms. In aiming to investigate cGMP signalling in neurones using the EGFP-based fluorescent biosensor, FlincG (fluorescent indicator for cGMP), we encountered weak or non-existent fluorescence afte...

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Bibliographic Details
Main Authors: Yogesh eBhargava, Kathryn eHampden-Smith, Konstantina eChachlaki, Katherine eWood, Jeffrey eVernon, Charles K Allerston, Andrew M Batchelor, John eGarthwaite
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Hippocampus
Neuroblastoma
Nitric Oxide
cGMP
Dorsal root ganglion
genetically-encoded biosensor
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2013.00026/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2013.00026/full

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