Discovering functional modules by identifying recurrent and mutually exclusive mutational patterns in tumors

<p>Abstract</p> <p>Background</p> <p>Assays of multiple tumor samples frequently reveal recurrent genomic aberrations, including point mutations and copy-number alterations, that affect individual genes. Analyses that extend beyond single genes are often restricted to e...

Full description

Bibliographic Details
Main Authors: Aldape Kenneth D, Sulman Erik P, Settle Stephen H, Miller Christopher A, Milosavljevic Aleksandar
Format: Article
Language:English
Published: BMC 2011-04-01
Series:BMC Medical Genomics
Online Access:http://www.biomedcentral.com/1755-8794/4/34