Macrophage lipoprotein lipase modulates the development of atherosclerosis but not adiposity

The role of macrophage lipoprotein lipase (LpL) in the development of atherosclerosis and adiposity was examined in macrophage LpL knockout (MLpLKO) mice. MLpLKO mice were generated using cre-loxP gene targeting. Loss of LpL in macrophages did not alter plasma LpL activity or lipoprotein levels. Inc...

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Bibliographic Details
Main Authors: Manabu Takahashi, Hiroaki Yagyu, Fumiko Tazoe, Shuichi Nagashima, Taichi Ohshiro, Kenta Okada, Jun-ichi Osuga, Ira J. Goldberg, Shun Ishibashi
Format: Article
Language:English
Published: Elsevier 2013-04-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520422151