The wasting‐associated metabolite succinate disrupts myogenesis and impairs skeletal muscle regeneration

The wasting‐associated metabolite succinate disrupts myogenesis and impairs skeletal muscle regeneration

Abstract Background Muscle wasting is a debilitating co‐morbidity affecting most advanced cancer patients. Alongside enhanced muscle catabolism, defects in muscle repair/regeneration contribute to cancer‐associated wasting. Among the factors implicated in suppression of muscle regeneration are cytok...

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Bibliographic Details
Main Authors: Paige C. Arneson‐Wissink, Kelly A. Hogan, Alexandra M. Ducharme, Adrienne Samani, Aminah Jatoi, Jason D. Doles
Format: Article
Language:English
Published: Wiley 2020-07-01
Series:JCSM Rapid Communications
Subjects:
Muscle wasting
Skeletal muscle
Succinate
Myogenesis
Online Access:https://doi.org/10.1002/rco2.14

Internet

https://doi.org/10.1002/rco2.14

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